Author

H. Garcia-Seisdedos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1 Organism:yeast· 1

Frequent Co-Authors

B. Ibarra-Molero· 1 shared E. D. Levy· 1 shared G. Shapira· 1 shared M. L. Romero-Romero· 1 shared S. Freud· 1 shared T. Levin· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 7 mutual co-author links

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1 shared paperBiophysics

B. Ibarra-Molero

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2 papers

Recent·Most cited

Active site center redesign increases protein stability preserving catalysis

M. L. Romero-Romero, H. Garcia-Seisdedos, B. Ibarra-Molero

This paper redesigns the active site of thioredoxin to increase protein stability while preserving catalytic activity through surface mutations.

bioRxiv · Jan 31, 2022Biophysics

Mutants libraries reveal negative design shielding proteins from mis-assembly and re-localization in cells

H. Garcia-Seisdedos, T. Levin, G. Shapira, S. Freud, E. D. Levy

The paper shows that surface mutations in homo-oligomeric proteins often cause mislocalization and misassembly, revealing negative design that shields against these effects.

bioRxiv · Jan 20, 2021Biophysics