Inhibition of Mitochondrial Fission Protein Drp1 Ameliorates Myopathy in the D2-mdx Model of Duchenne Muscular Dystrophy
H. Grace Rosen, NICOLAS J. A. BERGER, Shantel N. Hodge, Atsutaro A. Fujishiro, Jared Lourie, Vrusti Kapadia, Melissa A. Linden, Eunbin Jee, Jonghan Kim, Yuho Kim, Kai Zou
The paper shows that inhibiting Drp1-mediated mitochondrial fission with Mdivi-1 improves muscle strength and reduces damage in D2-mdx mice by enhancing mitochondrial integrity and reducing inflammation and fibrosis.
bioRxiv · Dec 26, 2024 · PreprintMolecular Biology