Molecular BiologybioRxivPreprint
Inhibition of Mitochondrial Fission Protein Drp1 Ameliorates Myopathy in the D2-mdx Model of Duchenne Muscular Dystrophy
H. Grace Rosen, NICOLAS J. A. BERGER, Shantel N. Hodge…·Kai Zou
The paper shows that inhibiting Drp1-mediated mitochondrial fission with Mdivi-1 improves muscle strength and reduces damage in D2-mdx mice by enhancing mitochondrial integrity and reducing inflammation and fibrosis.
6 citations