New Structure of Class II Fructose-1,6-Bisphosphatase from Francisella tularensis suggest a novel catalytic mechanism for the entire class
C. Abad-Zapatero, A. I. Selezneva, L. N. M. Harding, H. Gutka, F. Movahedzadeh
The paper presents crystal structures of FBPaseII from Francisella tularensis and Mycobacterium tuberculosis, revealing a revised catalytic mechanism involving a positive dipole rather than a metal cofactor for phosphate retention.
bioRxiv · Sep 5, 2022 · PreprintBiochemistry