Mutations generated by repair of Cas9-induced double strand breaks are predictable from surrounding sequence
F. R. Allen, L. R. Crepaldi, C. Alsinet-Armengol, A. Strong, V. Kleshchevnikov, P. De Angeli, P. Palenikova, M. Kosicki, A. R. Bassett, H. Harding, Y. Galanty, F. Munoz Martinez, E. Metzakopian, S. P. Jackson, L. Parts
The paper predicts Cas9-induced mutation outcomes based on surrounding DNA sequence using data from over 1 billion mutational outcomes.
bioRxiv · Aug 25, 2018 · PreprintCell Biology