Cholesterol interaction sites on the transmembrane domain of the hedgehog signal transducer and Class F G protein-coupled receptor Smoothened
G. Hedger, H. Koldsoe, M. Chavent, C. Siebold, R. Rohatgi, M. Sansom
The paper identifies cholesterol interaction sites on the transmembrane domain of the GPCR Smoothened using molecular dynamics simulations and free energy calculations.
bioRxiv · Aug 2, 2018Biophysics