Designed Transmembrane Proteins Inhibit the Erythropoietin Receptor in a Custom Binding Topology
M. Mravic, L. He, H. Kratochvil, H. Hu, S. E. Nick, W. Bai, A. Edwards, H. Jo, Y. Wu, D. DiMaio, W. F. DeGrado
The paper designs transmembrane proteins that inhibit the erythropoietin receptor by competing with homodimerization in a custom binding topology.
bioRxiv · Feb 13, 2023 · PreprintBioengineering