W. Bai

Multi-step engineered adeno-associated virus enables whole-brain mRNA delivery

This paper develops a system to package mRNAs into AAVs, enabling efficient whole-brain mRNA delivery in mice.

HNF&alpha is a target of the Wnt/beta-catenin pathway and regulates colorectal carcinogenesis

This study shows HNF4 is upregulated in colorectal cancer and promotes tumorigenesis by being activated by the Wnt/β-catenin pathway.

The EGF/EGFR-YAP1/TEAD2 axis-mediated BRAF inhibitor vemurafenib resistance upregulates STIM1 in melanoma

This study identifies the EGF/EGFR-YAP1/TEAD2 axis as a mechanism by which vemurafenib resistance upregulates STIM1 in melanoma.

Study on the preparation of bovine milk exosomes and the stability of lyophilized powder

This study prepares bovine milk exosomes and evaluates the stability of their lyophilized powder, showing it can be stored at room temperature for 3 months and 2-8°C for 15 months.

Mechanical Force Imprints Neutrophils to Orchestrate Pulmonary Homeostasis

This study identifies mechanical sensing via Piezo1 as critical for lung-specific neutrophils to maintain pulmonary homeostasis and respond to infection.

Improving bioplastic production by Rhodopseudomonas palustris TIE-1 using synthetic biology and metabolic engineering

This paper enhances bioplastic production in Rhodopseudomonas palustris TIE-1 through genetic modifications and a phage integration system.

The novel roles of bovine milk-derived exosomes on skin anti-aging

This study investigates the effects of bovine milk-derived exosomes on human skin anti-aging, showing they enhance moisture retention and reduce wrinkles while being safe for use.

Designed Transmembrane Proteins Inhibit the Erythropoietin Receptor in a Custom Binding Topology

The paper designs transmembrane proteins that inhibit the erythropoietin receptor by competing with homodimerization in a custom binding topology.

Sustainable Production of the Biofuel n-Butanol by Rhodopseudomonas palustris TIE-1

This study introduces an n-butanol biosynthesis pathway into Rhodopseudomonas palustris TIE-1 to produce biofuel from CO2 using sustainable resources.

Genetic redundancy in iron and manganese transport in the metabolically versatile bacterium Rhodopseudomonas palustris TIE-1

This study investigates Fe and Mn transport in Rhodopseudomonas palustris TIE-1, showing functional redundancy among transporters and their regulation by Fe and oxygen availability.

Epidemiology, Microbiology and Therapeutic Consequences of Chronic Osteomyelitis in Northern China: A Retrospective Analysis of 255 Patients

This study analyzes 255 chronic osteomyelitis patients in northern China, finding higher prevalence in males aged 41-50, common infection sites, and better outcomes with two-stage debridement and antibiotic-loaded PMMA beads.