Author

H. Leung

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Plant Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Organism:plant (other)· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Greenland· 1 shared A. Laurena· 1 shared A. Varshney· 1 shared B. Chong· 1 shared B. Gelfand· 1 shared B. Werner· 1 shared C. Stains· 1 shared E. Deomano· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperPlant Biology

A. Greenland

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Antithrombotic Efficacy and Bleeding Risks of Vaccine-Induced Immune Thrombotic Thrombocytopenia Treatments

H. Leung, Z. Ahmadi, J. Casey, S. Ratnasingam, S. McKenzie, J. Perdomo, B. Chong

This study evaluates anticoagulants and IVIg for treating VITT, finding danaparoid reduces IgG-PF4 binding and FcγRIIa blockade is most effective for thrombosis and thrombocytopenia.

bioRxiv · Apr 21, 2024Immunology

Identifying Novel Candidate Defense Genes Against Rice Blast By Disease-Resistance Transcriptome Analysis

R. P. Mauleon, K. Satoh, V. Bartolome, M. Baraoidan, E. Deomano, S. Kikuchi, H. Leung

The paper identifies novel defense genes against rice blast by analyzing disease-resistance transcriptomes in mutant and resistant rice cultivars, finding correlated gene expression regions associated with resistance QTLs.

bioRxiv · Oct 5, 2022 · PreprintPlant Biology

Identification of Fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration

M. Ambati, I. Apicella, S. Narendran, S.-b. Wang, H. Leung, F. Pereira, A. Varshney, M. Shadmehr, C. Stains, B. Werner, K. Baker, K. Marion, S. Sadda, E. Taylor, J. Magagnoli, , B. Gelfand

This paper identifies fluoxetine as a potential repurposed drug for dry AMD by showing it inhibits NLRP3-ASC inflammasome activation and reduces RPE degeneration in mice, supported by epidemiological data.

bioRxiv · Jan 11, 2021Immunology

cis dominantly explains regulatory divergence between two indica rice genotypes; drought further enhances regulatory differences

N. C. Ereful, A. Laurena, L.-y. Liu, S.-M. Kao, E. Tsai, M. Thomson, A. Greenland, W. Powell, I. Mackay, H. Leung

This study identifies cis and trans regulatory divergence between two indica rice genotypes under stress and non-stress conditions, showing cis dominance under normal conditions and increased trans effects under drought.

bioRxiv · Oct 18, 2020 · PreprintPlant Biology