Upregulated-flotillins and sphingosine kinase 2 derail vesicular trafic to stabilize AXL and promote epithelial-mesenchymal transition
M. Genest, F. Comunale, D. Planchon, P. Govindin, S. Vacher, I. Bieche, B. Robert, H. Malhotra, A. Schoenit, L. Tashireva, C. Gauthier-Rouviere, S. Bodin
The paper shows that flotillin overexpression and sphingosine kinase 2 promote AXL stabilization via altered vesicular trafficking, enhancing EMT in mammary epithelial cells.
bioRxiv · May 12, 2020Cell Biology