Mechanisms of Igf2 inhibition in thymic epithelial cells infected by coxsackievirus CV-B4
H. Michaux, A. Halouani, C. Trussart, C. Renard, H. Jaïdane, H. Martens, D. Hober, V. Geenen
This study investigates how CV-B4 infection affects Igf2 transcription in thymic epithelial cells, showing decreased Igf2 isoforms and promoter activity, and links this to reduced STAT3 signaling, potentially disrupting central self-tolerance.
bioRxiv · Jan 10, 2020 · PreprintMicrobiology