Author

H. Nakazawa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:machine learning (classical)· 2 Research Focus:protein design· 2 Assay:protein sequence· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

K. Tsuda· 2 shared M. Oikawa· 2 shared M. Umetsu· 2 shared T. Kameda· 2 shared Y. Saito· 2 shared E. Naru· 1 shared H. Ohnari· 1 shared J. Kamimoto-Kuroki· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBioengineering

K. Tsuda

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Author profile →

3 papers

Recent·Most cited

Low-flux electron diffraction study on the intercellular lipid organization in the human lip stratum corneum

J. Kamimoto-Kuroki, H. Nakazawa, H. Ohnari, M. Yamanoi, E. Naru, S. Kato

This study uses low-flux electron diffraction to analyze intercellular lipid organization in human lip stratum corneum, finding higher fluid-phase lipid proportions linked to lower water retention and chapping vulnerability.

bioRxiv · Sep 1, 2023 · PreprintBiophysics

Machine-learning-guided library design cycle for directed evolution of enzymes: the effects of training data composition on sequence space exploration

Y. Saito, M. Oikawa, T. Sato, H. Nakazawa, T. Ito, T. Kameda, K. Tsuda, M. Umetsu

This study shows that ML-guided directed evolution can lead to different enzyme variants depending on the presence of a highly positive variant in training data, achieving similar activity improvements.

bioRxiv · Aug 13, 2021Bioengineering

A machine-learning-guided mutagenesis platform for accelerated discovery of novel functional proteins

Y. Saito, M. Oikawa, H. Nakazawa, T. Niide, T. Kameda, K. Tsuda, M. Umetsu

The paper introduces a machine-learning-guided mutagenesis platform that accelerates discovery of functional proteins by using two rounds of mutagenesis informed by a trained model.

bioRxiv · Mar 16, 2018Bioengineering