Y. Saito

Fetal Kidney Transplantation for In Utero Fetuses

This paper describes a novel fetal therapy approach using transplanted fetal kidneys from different species to provide a bridge to dialysis in affected fetuses, demonstrating successful urine production and long-term function without immunosuppressants.

Human iPSC-derived Committed Cardiac Progenitors Generate Cardiac Tissue Grafts in a Swine Ischemic Cardiomyopathy Model without Triggering Ventricular Arrhythmias

The paper demonstrates that hiPSC-derived cardiac progenitor cells injected into swine hearts after MI form grafts that improve stress-induced contractile reserve without causing arrhythmias.

Can Colpoda travel across oceans? Salinity tolerance of resting cysts may enable global dispersal of the species.

The study investigates whether Colpoda cucullus resting cysts can tolerate saline conditions, suggesting a mechanism for oceanic dispersal of freshwater protists.

Endocytic vesicles act as vehicles for glucose uptake in response to growth factor stimulation

The paper shows that glucose uptake via GLUT1 co-endocytoses with PDGF receptor upon PDGF stimulation, delivering glucose to mitochondria for glycolysis.

descSPIM: Affordable and Easy-to-Build Light-Sheet Microscopy for Tissue Clearing Technique Users

The paper introduces descSPIM, a low-cost, easy-to-build light-sheet microscope for cleared tissue samples, enabling rapid 3D imaging.

Interactions between environmental sensitivity and gut microbiota are associated with biomarkers of stress-related psychiatric symptoms

The paper examines how interactions between environmental sensitivity and gut microbiota relate to inflammation and gut permeability biomarkers in adults.

Engineering the substrate specificity of toluene degrading enzyme XylM using biosensor XylS and machine learning

This paper uses a biosensor and machine learning to engineer XylM for improved substrate specificity, achieving 15 times higher productivity than the wild-type.

Proteomic profile of nuclei containing p62-positive inclusions in neuronal intranuclear inclusion disease

The paper identifies 20 proteins increased in nuclei with p62-positive inclusions in NIID using proteomic analysis and confirms their elevated expression via immunofluorescence.

Shaping neonatal immunization by tuning delivery of synergistic adjuvants via nanocarriers

This study identifies synergistic adjuvants for neonatal immunization using nanocarriers, showing enhanced Th1 bias and humoral responses in mice.

An adjuvanted SARS-CoV-2 RBD nanoparticle elicits neutralizing antibodies and fully protective immunity in aged mice

This study identifies an adjuvanted SARS-CoV-2 RBD nanoparticle that induces neutralizing antibodies and full protection in aged mice.

BITC induces cardiomyocyte proliferation and heart regeneration

This study shows that BITC induces cardiomyocyte proliferation and heart regeneration in neonatal and adult mice through CDK pathway activation and hypoxia-related signaling.

Machine-learning-guided library design cycle for directed evolution of enzymes: the effects of training data composition on sequence space exploration

This study shows that ML-guided directed evolution can lead to different enzyme variants depending on the presence of a highly positive variant in training data, achieving similar activity improvements.

Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity

This study evaluates AH:CpG adjuvant's ability to enhance RBD vaccine efficacy in aged mice and human elder cells, showing strong neutralizing antibody responses and cytokine production.

Preclinical study of DNA vaccines targeting SARS-CoV-2

This study evaluates a DNA vaccine targeting SARS-CoV-2 Spike protein, showing enhanced humoral and cellular immune responses and neutralizing antibody activity.

On-rate modulation of cadherin interactions by chemical fragments

This study identifies a chemical fragment that modulates the on-rate of P-cadherin dimerization by inhibiting cell adhesion.

SIRPalpha on mouse B1 cells restricts lymphoid tissue migration and natural antibody production

This study shows SIRPalpha on mouse B1 cells limits migration and natural antibody production, suggesting it as a therapeutic target for atherosclerosis.

Isolation of an archaeon at the prokaryote-eukaryote interface

The paper isolates an Asgard archaeon and proposes a symbiosis model for eukaryogenesis based on its morphology and metabolism.

Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

This study generates human hepatic progenitor cells from primary hepatocytes that can repopulate injured livers and redifferentiate into functional hepatocytes.

A machine-learning-guided mutagenesis platform for accelerated discovery of novel functional proteins

The paper introduces a machine-learning-guided mutagenesis platform that accelerates discovery of functional proteins by using two rounds of mutagenesis informed by a trained model.