Author

H. R. C. Screen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

C. T. Thorpe· 4 shared D. E. Zamboulis· 3 shared H. L. Birch· 3 shared P. D. Clegg· 3 shared D. Patel· 1 shared E. M. Spiesz· 1 shared L. Lenzi· 1 shared M. S. C. Godinho· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersCell Biology

C. T. Thorpe

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Author profile →

4 papers

Recent·Most cited

The interfascicular matrix of energy storing tendons houses heterogenous cell populations disproportionately affected by ageing

D. E. Zamboulis, N. Marr, L. Lenzi, H. L. Birch, H. R. C. Screen, P. D. Clegg, C. T. Thorpe

This study identifies IFM-resident cell populations in tendons and shows their age-related changes through single-cell RNA sequencing.

bioRxiv · Jan 4, 2023 · PreprintCell Biology

Structure-function Specialisation of the Interfascicular Matrix in the Human Achilles Tendon

D. Patel, D. E. Zamboulis, E. M. Spiesz, H. L. Birch, P. D. Clegg, C. T. Thorpe, H. R. C. Screen

This study shows the human Achilles tendon's interfascicular matrix is specialised for energy storage with increased elasticity and fatigue resistance, which diminish with age due to proteome changes.

bioRxiv · Feb 22, 2021Bioengineering

Elastase treatment of tendon specifically impacts the mechanical properties of the interfascicular matrix

M. S. C. Godinho, C. T. Thorpe, S. E. Greenwald, H. R. C. Screen

This study shows elastase treatment reduces elastin in tendon interfascicular matrix, decreasing its viscoelasticity, fatigue resistance, and recoverability, with no effect on fascicle mechanics.

bioRxiv · Sep 18, 2020Bioengineering

Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix

D. E. Zamboulis, C. T. Thorpe, Y. Ashraf Kharaz, H. L. Birch, H. R. C. Screen, P. D. Clegg

This study shows that postnatal mechanical loading primarily adapts connective tissues by modifying the non-collagenous matrix, not the collagen fibers.

bioRxiv · Apr 23, 2020Cell Biology