Author

P. D. Clegg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 7 Biochemistry· 1 Bioengineering· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 6 Assay:proteomics· 5 Organism:human· 4 Research Focus:differential expression· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:development & morphogenesis· 2

Frequent Co-Authors

C. T. Thorpe· 4 shared D. E. Zamboulis· 3 shared E. G. Canty-Laird· 3 shared H. L. Birch· 3 shared H. R. C. Screen· 3 shared K. J. Lee· 2 shared M. J. Peffers· 2 shared A. A. Pitsillides· 1 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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4 shared papersCell Biology

C. T. Thorpe

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

MskAge - An Epigenetic Biomarker of Musculoskeletal Age Derived from a Genetic Algorithm Islands Model

D. C. Green, L. Reynard, J. Henstock, S. Reppe, K. Gutvik, M. Peffers, D. Shanley, P. D. Clegg, E. G. Canty-Laird

This paper develops MskAge, an epigenetic biomarker for musculoskeletal age, showing higher accuracy than existing clocks in tracking in vitro ageing and reprogramming.

bioRxiv · May 4, 2023Cell Biology

Mesenchymal Stromal Cell secretome is affected by tissue source, donor age and sex.

A. J. Turlo, D. E. Hammond, K. A. Ramsbottom, J. Soul, A. Gillen, K. McDonald, M. J. Peffers, P. D. Clegg

This study identifies how donor age, sex, and tissue source affect the protein composition of equine mesenchymal stromal cell secretomes, with age showing the strongest impact.

bioRxiv · Jan 30, 2023Cell Biology

The interfascicular matrix of energy storing tendons houses heterogenous cell populations disproportionately affected by ageing

D. E. Zamboulis, N. Marr, L. Lenzi, H. L. Birch, H. R. C. Screen, P. D. Clegg, C. T. Thorpe

This study identifies IFM-resident cell populations in tendons and shows their age-related changes through single-cell RNA sequencing.

bioRxiv · Jan 4, 2023 · PreprintCell Biology

Structure-function Specialisation of the Interfascicular Matrix in the Human Achilles Tendon

D. Patel, D. E. Zamboulis, E. M. Spiesz, H. L. Birch, P. D. Clegg, C. T. Thorpe, H. R. C. Screen

This study shows the human Achilles tendon's interfascicular matrix is specialised for energy storage with increased elasticity and fatigue resistance, which diminish with age due to proteome changes.

bioRxiv · Feb 22, 2021Bioengineering

miR-24:Prdx6 interactions regulate oxidative stress and viability of myogenic progenitors during ageing

K. Goljanek-Whysall, A. Arroquia-Soriano, J. Gostage, D. Bardell, E. McCloskey, I. Bellantuono, P. D. Clegg, B. McDonagh

This study shows miR-24-3p and its target Prdx6 regulate oxidative stress and viability of myogenic progenitors during ageing, with miR-24 downregulation in old mice linked to increased ROS and satellite cell senescence.

bioRxiv · Jan 25, 2021 · PreprintCell Biology

Collagen (I) homotrimer potentiates the osteogenesis imperfecta (oim) mutant allele and reduces survival in male mice

K. J. Lee, L. Rambault, G. Bou-Gharios, P. D. Clegg, R. Akhtar, G. Czanner, R. J. van 't Hof, E. G. Canty-Laird

This study shows that homotrimeric collagen-1 in oim heterozygotes alleviates the mutant allele's effect, but genetic interaction causes bone fragility in oim homozygotes.

bioRxiv · Jul 13, 2020Physiology

Active synthesis of type I collagen homotrimer in Dupuytren's fibrosis is unaffected by anti-TNF-α treatment

K. Williamson, K. J. Lee, E. L. Beamish, A. Carter, J. A. Gumbs, G. Cooper, G. Cheung, D. Brown, R. Pettitt, E. J. Comerford, P. D. Clegg, E. G. Canty-Laird

This study investigates type I collagen synthesis in Dupuytrens disease and finds anti-TNF-α treatment does not reduce collagen production or prevent homotrimer formation.

bioRxiv · Jul 13, 2020Cell Biology

Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix

D. E. Zamboulis, C. T. Thorpe, Y. Ashraf Kharaz, H. L. Birch, H. R. C. Screen, P. D. Clegg

This study shows that postnatal mechanical loading primarily adapts connective tissues by modifying the non-collagenous matrix, not the collagen fibers.

bioRxiv · Apr 23, 2020Cell Biology

Ex-Vivo Equine Cartilage Explant Osteoarthritis Model - A Metabolomics and Proteomics Study

J. R. Anderson, M. M. Phelan, L. Foddy, P. D. Clegg, M. J. Peffers

This study uses metabolomics and proteomics to analyze ex-vivo equine cartilage explants treated with TNF-α/IL-1β, identifying differentially abundant metabolites and proteins associated with osteoarthritis pathogenesis.

bioRxiv · Mar 3, 2020Cell Biology

Heterogeneity of proteome dynamics between connective tissue phases of adult tendon

D. Simpson, H. Choi, D. Wang, M. Prescott, A. A. Pitsillides, J. Dudhia, P. D. Clegg, P. Ping, C. T. Thorpe

The paper measures protein turnover rates in collagen and glycoprotein phases of rat Achilles tendon using isotope labeling and mass spectrometry, finding significant differences in proteome dynamics between the two ECM phases.

bioRxiv · Jan 27, 2020Biochemistry