Author

K. S. Makarova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 6 Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

E. V. Koonin· 7 shared J. Bondy-Denomy· 3 shared Y. I. Wolf· 3 shared S. A. Shmakov· 2 shared S. Shmakov· 2 shared A. Fossati· 1 shared A. Gussow· 1 shared A. Kirillov· 1 shared

Activity by Year

2016-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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7 shared papersMicrobiology

E. V. Koonin

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Author profile →

8 papers

Recent·Most cited

CoCoNuTs: A diverse subclass of Type IV restriction systems predicted to target RNA

R. T. Bell, H. Sahakyan, K. S. Makarova, Y. I. Wolf, E. V. Koonin

The paper identifies and characterizes CoCoNuTs, a new subclass of Type IV restriction systems that target RNA, with additional potential DNA targeting capabilities and regulatory mechanisms.

bioRxiv · Jul 31, 2023Microbiology

Activation of programmed cell death and counter-defense functions of phage accessory genes

S. Silas, H. Carion, K. S. Makarova, E. Laderman, D. S. Godinez, M. Johnson, A. Fossati, D. Swaney, M. Bocek, E. V. Koonin, J. Bondy-Denomy

The paper identifies and characterizes phage accessory genes (AGs) that activate host antiviral immunity, including programmed cell death, and explores their evolutionary implications.

bioRxiv · Apr 6, 2023 · PreprintMicrobiology

A family of novel immune systems targets early infection of nucleus-forming jumbo phages

Y. Li, J. Guan, S. Hareendranath, E. Crawford, D. A. Agard, K. S. Makarova, E. V. Koonin, J. Bondy-Denomy

This study identifies a novel immune system, Juk, in Pseudomonas aeruginosa that targets jumbo phages by inhibiting early phage transcription, DNA replication, and nucleus assembly.

bioRxiv · Sep 17, 2022 · PreprintMicrobiology

tRNA anticodon cleavage by target-activated CRISPR-Cas13a effector

I. Jain, M. Kolesnik, L. Minakhin, N. Morozova, A. Shiriaeva, A. Kirillov, S. Medvedeva, K. Kuznedelov, S. Borukhov, K. S. Makarova, E. V. Koonin, K. Severinov, E. Semenova

The paper shows that Cas13a cleaves tRNA anticodons to induce bacterial dormancy and activates toxin-antitoxin modules for mRNA and rRNA cleavage.

bioRxiv · Nov 10, 2021Microbiology

Vast diversity of anti-CRISPR proteins predicted with a machine-learning approach

A. Gussow, S. A. Shmakov, K. S. Makarova, Y. I. Wolf, J. Bondy-Denomy, E. V. Koonin

The paper predicts 2,500 novel anti-CRISPR protein families using a machine learning approach and validates one candidate's anti-CRISPR activity.

bioRxiv · Jan 23, 2020 · PreprintMicrobiology

Recruitment of CRISPR-Cas systems by Tn7-like transposons

J. E. Peters, K. S. Makarova, S. Shmakov, E. V. Koonin

The paper identifies CRISPR-Cas systems within Tn7-like transposons, showing they are truncated and function in pre-crRNA processing but not target cleavage, and proposes a mechanism for their role in transposon spread.

bioRxiv · Jun 23, 2017Evolutionary Biology

The CRISPR Spacer Space Is Dominated By Sequences From The Species-Specific Mobilome

S. A. Shmakov, V. Sitnik, K. S. Makarova, Y. I. Wolf, K. V. Severinov, E. Koonin

The study analyzes CRISPR spacers across bacterial and archaeal genomes, finding most target mobile genetic elements and showing strong compositional correlations with microbial and viral genomes.

bioRxiv · May 12, 2017Microbiology

Cas13b is a Type VI-B CRISPR-associated RNA-Guided RNase differentially regulated by accessory proteins Csx27 and Csx28

A. Smargon, D. B. T. Cox, N. Pyzocha, K. Zheng, I. M. Slaymaker, J. S. Gootenberg, O. A. Abudayyeh, P. Essletzbichler, S. Shmakov, K. S. Makarova, E. V. Koonin, F. Zhang

The paper identifies two CRISPR-Cas VI-B systems with Cas13b and characterizes their RNA interference activity and regulation by Csx27 and Csx28.

bioRxiv · Dec 9, 2016Microbiology