Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation
M. Bhattacharyya, Y. K. Lee, S. Muratcioglu, B. Qiu, P. Nyayapati, H. Schulman, J. T. Groves, J. Kuriyan
This study shows that differences in kinase-hub linker lengths between CaMKII and CaMKII-β isoforms affect their autophosphorylation balance, with CaMKII favoring activation and CaMKII-β favoring inhibition.
bioRxiv · Nov 20, 2019Biophysics