Author

H. Shan

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Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

H. E. Xu· 1 shared J. Li· 1 shared J. Shen· 1 shared K. Wang· 1 shared K. Wu· 1 shared L. Zhao· 1 shared Q. He· 1 shared Q. Yuan· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

H. E. Xu

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1 paper

Recent·Most cited

A conserved and druggable pocket in class B G protein coupled receptors for orally active small molecule agonists

H. E. Xu, L. Zhao, Q. He, Q. Yuan, Y. Gu, X. He, H. Shan, J. Li, K. Wang, Y. Li, W. Hu, K. Wu, J. Shen

This study identifies a conserved binding pocket in class B GPCRs that enables small molecule agonists like PCO371 to activate G proteins without triggering arrestin signaling.

bioRxiv · Jun 8, 2023 · PreprintBiochemistry