Q. Yuan

Engineering One-Signal Activated TILs with CD3ζ-CD28 Chimeras Optimizes the Antitumor Efficacy of TIL-Based Immunotherapy

This paper engineers one-signal-activated TILs with CD3ζ-CD28 chimeras to enhance antitumor efficacy in immunotherapy.

SHOOTMERISTEMLESS autoactivation: A prerequisite for fruit metamorphosis

The paper shows that CrSTM autoactivation through a cis regulatory element is essential for Capsella fruit shape transition during metamorphosis.

Structure basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor

This study determines the cryo-EM structure of QRFPR bound to 26RFa, revealing the recognition mechanism and aiding drug design for obesity and diabetes.

A conserved and druggable pocket in class B G protein coupled receptors for orally active small molecule agonists

This study identifies a conserved binding pocket in class B GPCRs that enables small molecule agonists like PCO371 to activate G proteins without triggering arrestin signaling.

Design, evaluation and implementation of synthetic isopentyldiol pathways in Escherichia coli

The paper designs and evaluates synthetic isopentyldiol pathways in E. coli, finding that a computationally designed pathway produces IPDO at 2.2 mg/L from glucose.

Lack of Fzd6 in Ciliated Cells Suppresses Ferroptotic Pulmonary Alveolar Cell Death Induced by LPS and Coronavirus

This study shows that Fzd6 deficiency in ciliated cells reduces pulmonary inflammation-induced cell death by increasing Akr1b8 expression and protecting against ferroptosis.

Illumination of the complement receptors C3aR and C5aR signaling by anaphylatoxins

This study reports the structures of C3a-bound C3aR and C5a-bound C5aR1, revealing their ligand recognition and activation mechanisms.

LDL Receptor-Related Protein 5 is a Selective Transporter for Unesterified Polyunsaturated Fatty Acids

This study identifies LRP5 as a selective transporter for unesterified PUFAs, showing its role in mTORC1 inhibition and protection against myocardial injury.

SAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum

The paper identifies SAYSD1 as a sensor of ribosome UFMylation that facilitates TAQC by interacting with the translocon and UFM1 to degrade stalled proteins, maintaining ER homeostasis.

Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

Rapid generation of CD19 CAR-T Cells by minicircle DNA enables anti-tumor activity and prevents fatal CAR-B leukemia

This study develops a method using minicircle DNA to rapidly generate CD19 CAR-T cells that are effective and safe, avoiding genomic integration risks.

Structure of a G protein-coupled receptor with GRK2 and a biased ligand

The paper reports the structure of NTSR1 bound to GRK2, Gq, and a biased ligand, revealing how the ligand enhances GRK2 binding and enables arrestin-biased signaling.

Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1

The paper reports cryo-EM structures of PTH1R bound to PTH and PTHrP, revealing molecular mechanisms of hormone recognition and selectivity.

Intranasal delivery of NS1-deleted influenza virus vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response

This study evaluates an intranasal influenza-based vaccine against SARS-CoV-2 variants, showing it reduces inflammatory response and tissue damage through local immunity.

Creating an atlas of the bone microenvironment during oral inflammatory-related bone disease using single-cell profiling

This study creates a single-cell atlas of the bone microenvironment in healthy and inflammatory states, identifying key MSC subclusters and their biomarkers in apical periodontitis.

Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.1 and BA.2 variants and their mouse origins

This study investigates the structural and biochemical features of Omicron BA.1 and BA.2 variants, showing increased infectivity and mouse ACE2 binding compared to wildtype, suggesting a potential human-cat-mouse-human transmission cycle.

Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody: mechanisms for the high infectivity, immune evasion and antibody drug discovery

A live attenuated influenza virus-vectored intranasal COVID-19 vaccine provides rapid, prolonged, and broad protection against SARS-CoV-2 infection

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

Quantitation of human enteric viruses as alternative indicators of fecal pollution to evaluate wastewater treatment processes

The paper quantifies human enteric viruses in wastewater samples to assess their potential as indicators of fecal pollution and evaluates their reduction across treatment stages.

Quantatitive Analysis of Conserved Sites on the SARS-CoV-2 Receptor-Binding Domain to Promote Development of Universal SARS-Like Coronavirus Vaccines

The paper identifies conserved antigenic sites in SARS-CoV-2 and SARS-CoV RBDs and designs RBD variants to improve immunogenicity for universal vaccine development.

Sterilizing immunity against SARS-CoV-2 in hamsters conferred by a novel recombinant subunit vaccine

This paper develops a subunit vaccine against SARS-CoV-2 that induces sterilizing immunity in hamsters, with high neutralizing antibody titers and protection against infection and symptoms.

A comparison of Remdesivir versus Au22Glutathione18 in COVID-19 golden hamsters: a better therapeutic outcome of gold compound

This study compares the therapeutic effects of Remdesivir and Au22Glutathione18 in COVID-19 golden hamsters, finding that the gold compound better suppresses viral replication and inflammation.

ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming

The paper identifies ERG's role in prostate cancer by showing it inhibits basal cell differentiation through chromatin interactions, promoting luminal cell fate.

Robust neutralization assay based on SARS-CoV-2 S-bearing vesicular stomatitis virus (VSV) pseudovirus and ACE2-overexpressed BHK21 cells

This paper develops a robust neutralization assay using SARS-CoV-2 S-bearing VSV pseudovirus and ACE2-overexpressed BHK21 cells to screen antibodies and quantify neutralizing titers.

Virus-free and live-cell visualizing SARS-CoV-2 cell entry for studies of neutralizing antibodies and compound inhibitors

This study develops a virus-free live-cell visualization system for SARS-CoV-2 entry using a fluorescent spike trimer probe, enabling analysis of neutralizing antibodies and inhibitors.

Continental-scale microbiome study reveals different environmental characteristics determining microbial richness and composition/quantity in hotel rooms

This study characterizes the microbial composition and environmental factors in hotel rooms across continents, finding associations between fungal and bacterial diversity, quantity, and environmental characteristics.

Several FDA-approved drugs effectively inhibit SARS-CoV-2 infection in vitro

This study evaluates 1403 FDA-approved drugs for SARS-CoV-2 inhibition using pseudovirus and authentic virus assays, identifying four compounds with potent effects and a synergistic combination.

Derived ecological niches of indoor microbes are crucial for asthma symptoms in university dormitories

The study links indoor microbial communities in university dormitories to asthma symptoms, finding specific taxa from different ecological niches are associated with increased or protective effects on asthma.

Distinct microbiome composition of floor and air dust distort richness estimation in university dormitories

This study compares microbial composition in floor and air dust from university dormitories, showing significant differences that affect downstream microbiome analysis.

Integrated Low-Energy and Low Carbon Shortcut Nitrogen removal with Biological Phosphorus Removal for Sustainable Mainstream Wastewater Treatment

The paper demonstrates efficient combined nitrogen, phosphorus, and chemical oxygen demand removal in a wastewater treatment system using anaerobic-aerobic cycling and nitritation-denitritation without exogenous chemicals.