CRISPR-Cas12a-Based Rapid and Sensitive Detection of rpoBL378R in Mycobacterium tuberculosis
Y. h. Yang, L. Yang, X. y. Li, J. Tang, Y. Zhu, K. Ma, Y. m. Yang, Z. y. Hui, Y. y. Qin, H. t. Lei, M. h. Shan
This paper develops a CRISPR-Cas12a-based detection system to identify the rpoBL378R mutation in Mycobacterium tuberculosis, showing high specificity and sensitivity for drug-resistant strains.
bioRxiv · Jun 6, 2023 · PreprintMicrobiology