H. T. Ton

TRPV1 in arteries enables a rapid myogenic tone

This study identifies TRPV1 as essential for rapid myogenic tone in heart and skeletal muscle arteries, showing TRPV1 antagonists reduce tone and that TRPV1 mediates stretch-induced Ca2+ signaling and vasoconstriction.

TRPV1 expressed throughout the arterial circulation enables inflammatory vasoconstriction

This study identifies TRPV1 expression in vascular smooth muscle and demonstrates its role in inflammatory vasoconstriction and systemic blood pressure regulation.