Development of an exosomal gene signature to detect residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning
K. Makielski, A. J. Donnelly, A. Khammanivong, M. C. Scott, A. R. Ortiz, D. C. Galvan, H. Tomiyasu, C. Amaya, K. Ward, A. Montoya, J. R. Garbe, L. J. Mills, G. R. Cutter, J. M. Fenger, W. C. Kisseberth, , J. F. Modiano
The paper develops a gene signature using exosomal RNA from canine osteosarcoma xenografts and machine learning to detect residual disease in dogs, showing improved remission outcomes in validation samples.
bioRxiv · Feb 11, 2021Cancer Biology