A. Montoya

GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function

This study shows GLP-1R agonists improve mitochondrial health in beta-cells by forming a complex with VAPB and SPHKAP at ER-mitochondria MCSs, leading to mitochondrial remodelling and improved function.

Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity

This study identifies differential CpG methylation at the Nnat gene as a mechanism establishing beta cell heterogeneity during development and its potential role in diabetes.

Development of an exosomal gene signature to detect residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning

The paper develops a gene signature using exosomal RNA from canine osteosarcoma xenografts and machine learning to detect residual disease in dogs, showing improved remission outcomes in validation samples.

Indisulam targets RNA splicing and metabolism to serve as a novel therapeutic strategy for high-risk neuroblastoma

This study shows that indisulam, a sulphonamide, targets RNA splicing and metabolism to inhibit neuroblastoma growth and achieve complete tumor remission in preclinical models.

A conserved activity for cohesin in bridging DNA molecules

This study identifies a conserved DNA bridging activity of cohesin complexes across species, revealing two bridge types with distinct force resistance and functional implications for cohesion and chromosome architecture.

TRF1 prevents permissive DNA damage response, recombination and Break Induced Replication at telomeres

This study shows TRF1 prevents DNA damage response, recombination, and break-induced replication at telomeres by suppressing PML, BRCA1, and SMC5/6 complex accumulation.