Establishing Preclinical Withdrawal Syndrome Symptomatology Following Heroin Self-Administration in Male and Female Rats
C. D. Gipson, K. E. Dunn, A. H. Bull, H. Ulangkaya, A. Hossain
This study characterizes opioid withdrawal symptoms in male and female rats following heroin self-administration and abrupt discontinuation, revealing sex-specific differences in acute and protracted withdrawal.
bioRxiv · Mar 2, 2020Animal Behavior & Cognition