Modelling the Erythroblastic Island Niche of Dyserythropoietic Anaemia Type IV patients using Induced Pluripotent Stem Cells
A. May, T. Ventura, A. Fidanza, H. Volmer, H. A. Taylor, N. Romano, S. L. D'Souza, J. J. Bieker, L. M. Forrester
This study uses iPSCs to model CDA type IV, showing KLF1-E325K mutations impair erythroid cell production and slightly affect macrophage maturation in the EBI niche.
bioRxiv · Feb 2, 2023Cell Biology