Breast Cancer Cells and Macrophages in a Paracrine-Juxtacrine Loop
S. Onal, M. Turker-Burhan, G. Bati-Ayaz, H. Yanik, D. Pesen-Okvur
This study investigates interactions between breast cancer cells and macrophages, revealing a paracrine-juxtacrine loop involving CSF-1 and EGF, with macrophages showing chemotaxis toward cancer cells and direct contact required for EGF signaling.
bioRxiv · Jun 16, 2020Cancer Biology