The biosynthetic gene cluster of the C-nucleoside antibiotic pyrazomycin with a rare pyrazole moiety
G. Zhao, S. Yao, K. W. Rothchild, T. Liu, Y. Liu, J. Lian, H.-Y. He, K. S. Ryan, Y.-L. Du
This study identifies the gene cluster and key enzymes involved in pyrazomycin biosynthesis in Streptomyces candidus, revealing the role of PyrR as a transcriptional activator and PyrN as a nitrogen-nitrogen bond-forming enzyme.
bioRxiv · Jul 18, 2019Biochemistry