Phosphorylation modulates estrogen receptor disorder by altering long-range hydrophobic interactions
Z. Du, H. Wang, C. Wu, M. Buck, W. Zheng, A. L. Hansen, H.-Y. Kao, S. Yang
This study shows phosphorylation at Ser118 of the estrogen receptor's disordered N-terminal domain alters long-range hydrophobic interactions, leading to conformational changes that activate transcriptional function.
bioRxiv · Jul 14, 2023Biophysics