H. Wang

Orphan GPR84 facilitates uropod de-adhesion to terminate leukocyte diapedesis during inflammation

This study identifies GPR84 as a regulator of immune cell extravasation by enabling uropod de-adhesion during inflammation, showing its role in terminating leukocyte migration.

Localization of Mutant Huntingtin with HTT Exon1 P90 C-terminal Neoepitope Antibodies in Relation to Regional and Neuronal Vulnerability in Forebrain in Q175 Mice and Human Huntington's Disease

The paper uses specific antibodies to detect mutant huntingtin fragments in HD mouse models and human brains, showing regional and neuronal differences in accumulation that correlate with vulnerability.

Wave succession in the pandemic clone of Vibrio parahaemolyticus driven by gene loss

The paper investigates gene loss in Vibrio parahaemolyticus pandemic clones, showing it drives wave succession through environmental and transmission advantages.

BMP9 and BMP10 coordinate liver cellular crosstalk to maintain liver health

This study shows that HSCs produce BMP9/10, which regulate KCs and ECs to maintain liver homeostasis, and their deletion leads to fibrosis and iron overload.

Biologically-informed deep neural networks provide quantitative assessment of intratumoral heterogeneity in post-treatment glioblastoma

This paper develops BioNet, a biologically-informed deep learning model, to predict intratumoral heterogeneity in post-treatment glioblastoma using MRI and biopsy data, showing improved performance over existing methods.

SREBP-dependent regulation of lipid homeostasis is required for progression and growth of pancreatic ductal adenocarcinoma

This study shows that SREBP pathway inhibition slows PDAC tumor growth by disrupting lipid homeostasis, suggesting SCAP as a therapeutic target.

Structure of yeast RAVE bound to a partial V1 complex

The paper determines the structure of yeast RAVE bound to a partial V1 complex using cryo-EM, revealing its role in facilitating V1-VO reassociation.

Bioadhesive Hydrogel-Coupled and Miniaturized Ultrasound Transducer System for Long-Term, Wearable Neuromodulation

This paper develops a wearable ultrasound device with bioadhesive hydrogel for long-term neuromodulation, demonstrating its effectiveness in suppressing somatosensory responses over 28 days.

Macrophage-derived CCL24 promotes fibrosis and worsens cardiac dysfunction during heart failure

This study shows that macrophage-derived CCL24 worsens fibrosis and cardiac dysfunction in heart failure by activating fibroblasts through the CCR3 receptor.

Toward industrial C8 production: Oxygen intrusion drives renewable n caprylate production from ethanol and acetate via intermediate metabolite production

This study identifies oxygen's role in enabling renewable n-caprylate production from ethanol and acetate via intermediate metabolite synthesis in bioreactors.

Synchronous assembly of peptide anisosome

This study reports the formation of symmetrical core-shell biomolecular condensates through programmed tetra-peptide libraries and identifies tryptophan's role in structuring these condensates.

Wide-field bond-selective fluorescence imaging: from single-molecule to cellular imaging beyond video-rate

This paper introduces WF-BonFIRE, a wide-field bond-selective fluorescence imaging technique that achieves single-molecule sensitivity and kilohertz speeds for live-cell and bacterial imaging.

Fully-Automated Multicolour Structured Illumination Module for Super-resolution Microscopy

This paper presents an open-source, fully-automated two-color structured illumination module for super-resolution microscopy, achieving 1.55-fold improved lateral resolution over conventional wide-field microscopy.

The fully activated open state of KCNQ1 controls the cardiac 'fight-or-flight' response

This paper identifies the fully activated open state of KCNQ1 as critical for β-adrenergic stimulation of IKs channels, showing that modulators enhancing this state can restore function in LQT1 mutants.

Linker histone H1-0 is a specific mediator of the repressive ETV6::RUNX1 transcriptional landscape

This study identifies H1-0 as a mediator of ETV6::RUNX1-induced quiescence in BCP-ALL preleukemic cells and suggests HDACi treatment as a potential therapeutic approach.

Polymerization of Tetraspanin 7 into Helical Transmembrane Skeletons for Tubular Membrane Stabilization

The paper identifies TSPAN7's role in forming helical transmembrane structures that stabilize tubular membrane protrusions by sensing curvature and resisting mechanical stress.

Genomic evolution reshapes cell type diversification in the amniote brain

The paper creates a single-cell atlas of amniote brains to study cell type diversification and identifies species-specific gene expression patterns and novel cell subtypes.

Multiomics mapping and characterization of cellular senescence in aging human skeletal muscle uncovers a novel senotherapeutic for sarcopenia

This study uses single-nucleus multiomics to characterize senescence in human skeletal muscle, identifies SASP factors, and proposes Maraviroc as a senotherapeutic for sarcopenia.

Changes in urinary proteome in healthy individuals taking multi-vitamin/mineral supplements

This study shows that taking multi-vitamin/mineral supplements for 2 or 4 weeks changes the urinary proteome, with erythropoietin receptor levels increasing significantly in some individuals.

Calorie Restriction Induces Degeneration of Neurons with Mitochondrial DNA Depletion by Altering ER-Mitochondria Calcium Transfer

This study shows that calorie restriction exacerbates neuronal degeneration in mtDNA-depleted neurons by increasing ER-mitochondria calcium transfer, suggesting CR may not be beneficial for mitochondrial epilepsy.

Microbiota metabolized Bile Acids accelerate Gastroesophageal Adenocarcinoma via FXR inhibition

This study shows that high-fat diets promote GEAC by altering the microbiota-Bile Acid axis and inhibiting FXR, with FXR agonists like OCA slowing disease progression.

Distribution, Prevalence of Non-Tuberculous Mycobacteria in Hainan Island and Antibiotic Resistance of Mycobacterium abscessus

This study maps NTM distribution and antibiotic resistance in Hainan Island, identifying key species and resistance patterns to inform regional surveillance and treatment.

Muscone-specific olfactory protein reveals the putative scent-marking pheromone in the Sunda pangolin (Manis javanica)

This study identifies muscone as a potential male-specific scent-marking pheromone in Sunda pangolins through functional expression of odorant-binding proteins and behavioral assays.

Single-cell dissection of prognostic architecture and immunotherapy response in Helicobacter pylori infection associated gastric cancer

This study analyzes single-cell transcriptomes of gastric cancer with and without H. pylori infection to identify immune and angiogenic signatures predictive of immunotherapy response.

Structural and Biophysical Dynamics of Fungal Plasma Membrane Proteins and Implications for Echinocandin Action in Candida glabrata

This study investigates the structural and dynamic organization of plasma membrane proteins in Candida glabrata using cryo-ET and live cell imaging, revealing how echinocandin drugs affect their distribution and function.

Pharmacodynamic modeling of colistin and imipenem against in vitro Pseudomonas aeruginosa biofilms

This study develops a PK-PD model for imipenem and colistin against Pseudomonas aeruginosa biofilms to optimize clinical dosing schedules.

Exploring Integrin α5β1 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension: Insights from Comprehensive Multicenter Preclinical Studies

The study identifies integrin α5β1 as a key driver of pulmonary vascular remodeling in PAH and shows its inhibition improves hemodynamics and RV function in preclinical models.

Modular Design and Scaffold-Synthesis of Multi-Functional Fluorophores for Targeted Cellular Imaging and Pyroptosis

This study designs and synthesizes functional fluorophores using a scaffold-based Ugi reaction, enabling detection of reactive-oxygen species and controlled subcellular localization, with some compounds showing pyroptosis-inducing activity in cancer cells.

Epidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxic Acute Lung Injury

This study shows that EGFR regulates Beclin-1 and autophagy in hyperoxic acute lung injury, suggesting a novel therapeutic pathway.

Effect of autonomous consumption of different sweet substances on the urinary proteome of mice

This study examines how different sweet substances affect the urinary proteome of mice, finding distinct proteomic changes associated with each sweetener.