W. Zheng

Golgi-associated retrograde protein (GARP) complex recruits retromer to trans-Golgi network for FgKex2 and FgSnc1 recycling, necessary for development and pathogenicity of Fusarium graminearum

This study identifies the GARP complex as a mediator that recruits retromer to the trans-Golgi network, facilitating the recycling of FgKex2 and FgSnc1, which is essential for growth, development, and pathogenicity of Fusarium graminearum.

An arms race between 5'ppp-RNA virus and its alternative recognition receptor MDA5 in RIG-I-lost teleost fish

The paper examines the evolutionary arms race between 5'ppp-RNA virus and the MDA5 receptor in RIG-I-lost teleost fish, showing how MDA5 compensates for RIG-I loss and how the virus counteracts this through m6A methylation.

Phase Separation and Aggregation of α-Synuclein Diverge at Different Salt Conditions

This study investigates how salt concentration affects the phase separation and aggregation of alpha-synuclein, revealing distinct salt dependencies and dynamic transitions between assembly states.

Super Pangenome of Grapevines Empowers Improvement of the Oldest Domesticated Fruit

The paper assembles and annotates haplotype-resolved genomes of grapevines to uncover genetic diversity and disease resistance mechanisms, identifying structural variants linked to downy mildew resistance.

The assembly and efflux processes revealed by in situ structures of the ABC-type tripartite pump MacAB-TolC

The paper resolves the in situ structures of the MacAB-TolC efflux pump in E. coli, revealing its assembly process and substrate-driven efflux mechanism.

The ICF2 gene Zbtb24 specifically regulates the differentiation of B1 cells via promoting heme synthesis

This study shows that Zbtb24 regulates B1 cell differentiation via heme synthesis, leading to impaired antibody production in T-cell independent responses.

Defining metabolic flexibility in hair follicle stem cell induced squamous cell carcinoma

This study investigates metabolic flexibility in hair follicle stem cell-derived squamous cell carcinoma by blocking glycolysis and glutaminolysis, showing tumors can compensate by upregulating lactate consumption.

Cell context-specific Synthetic lethality Prediction and Mechanism Analysis

This paper introduces SLWise, a deep-learning model for predicting synthetic lethal interactions in specific cellular contexts, and SLAD-CE for analyzing their mechanisms, showing improved accuracy over existing methods.

Large pilin subunits provide distinct structural and mechanical properties for the Myxococcus xanthus type IV pilus

This study solves the structure of Myxococcus xanthus type IV pilus and shows its increased rigidity due to a large C-terminal domain in PilA, enhancing motility on varied surfaces.

Phosphorylation modulates estrogen receptor disorder by altering long-range hydrophobic interactions

This study shows phosphorylation at Ser118 of the estrogen receptor's disordered N-terminal domain alters long-range hydrophobic interactions, leading to conformational changes that activate transcriptional function.

Opposing implications of co-evolutionary lineages and traits of gut microbiome on human health status

The paper compares co-evolutionary lineages of gut microbes in wild primates and humans, revealing opposing health implications of specific microbial traits.

Sex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development

The paper compares placental transcriptomes and histology between native Tibetans and Han migrants, finding sex-biased expression divergence and adaptive histological changes in male-infant placentas.

Functional and metagenomic level diversities of human gut symbiont-derived glycolipids

The paper investigates the functional and metagenomic diversity of glycolipids produced by gut symbionts, revealing distinct biosynthetic pathways and immune-modulatory roles of different microbial species.

Multimodal engineering of extracellular vesicles for efficient intracellular protein delivery

This paper develops VEDIC and VFIC systems for efficient intracellular protein delivery using engineered extracellular vesicles, achieving high recombination and genome editing efficiency in vitro and in vivo.

Widespread PRC barrel proteins play critical roles in archaeal cell division

This study identifies three PRC barrel proteins in Haloferax volcanii essential for archaeal cell division, showing their conservation and role in division across haloarchaea.

Mammalian Esophageal Stratified Tissue Homeostasis is Maintained Distinctively by the Epithelial Pluripotent p63+Sox2+ and p63-Sox2+ Cell Populations

This study identifies two distinct cell populations, p63+Sox2+ and p63-Sox2+, that maintain esophageal tissue homeostasis through different roles in stemness, differentiation, and damage repair.

Dihydroartemisinin inhibits EMT of glioma via gene BASP1 in extrachromosomal DNA

This study shows DHA inhibits glioma migration and invasion by upregulating ecDNA-BASP1, which suppresses EMT.

Cryo-EM of α-tubulin isotype containing microtubules revealed a contracted structure of α4A/β2A microtubules

The paper determines cryo-EM structures of microtubules composed of different α-tubulin isotypes and finds that α4A/β2A microtubules show longitudinal contraction compared to other isotype combinations.

Microbiome induced complement synthesized in the gut protects against enteric infections

The paper shows gut microbiota regulate complement component 3 (C3) production in humans and mice, with intestinal C3 levels correlating with protection against enteric infections.

Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection

This study identifies lysosome-poor monocyte-derived lung cells as a niche for Mtb persistence during chronic infection, suggesting a target for host-directed therapy.

In situ structures of secretins from bacterial type II secretion system reveal their membrane interactions and translocation process

The paper determines in situ structures of GspD and GspDβ secretins during translocation, revealing distinct membrane interaction patterns and translocation mechanisms.

Interpreting Transient Interactions of Intrinsically Disordered Proteins

This study investigates how transient interactions in intrinsically disordered proteins affect their conformational properties and develops a new polymer model to better interpret experimental data.

Development of an affinity-enhanced clinical candidate TCR targeting NY-ESO-1 with optimal potency and high specificity

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

Deep Learning model accurately classifies metastatic tumors from primary tumors based on mutational signatures

The paper develops a deep learning model that classifies metastatic tumors from primary tumors using mutational signatures from genomic data.

The porcine cGAS-STING pathway exerts an unusual antiviral function independent of IFN and autophagy

This study shows porcine STING has antiviral activity independent of IFN and autophagy, and also triggers apoptosis to resist viral infections.

Complex functional phenotypes of NMDA receptor disease variants

This study investigates how specific NMDA receptor variants affect receptor function through molecular dynamics and electrophysiology, revealing that altered interactions at P552 and F652 lead to complex functional deficits.

Rab7/Retromer-based endolysosomal trafficking facilitates effector secretion and host invasion in rice blast

This study identifies a novel endolysosomal trafficking pathway in Magnaporthe oryzae that facilitates effector secretion and host invasion via Rab7/Retromer/MoSnc1-mediated vesicle transport.

Root twisting drives halotropism via stress-induced microtubule reorientation

This study identifies the molecular mechanism of root halotropism in Arabidopsis, showing that ABA-mediated microtubule reorientation drives anisotropic cell expansion and root twisting in response to salt stress.

The SARS-CoV-2 spike protein binds and modulates estrogen receptors

This study identifies a novel interaction between SARS-CoV-2 spike protein and estrogen receptor alpha, showing its role in modulating ER activity and ACE2 expression in infected cells and tissues.

Profiling the size-dependent heterogeneity of membrane proteins in a mixed population of small extracellular vesicle for potential cancer diagnosis

This study profiles size-dependent membrane protein heterogeneity in small EVs to improve cancer diagnosis accuracy using a novel single EV enumeration approach.