Aberrant transcript usage induces homologous recombination deficiency and predicts therapeutic responses
Hyeon Gu Kang, Haeun Hwangbo, Myung Ji Kim, Sinae Kim, Eun Ji Lee, Min Ji Park, Jae-Weon Kim, Byoung-Gie Kim, Eun-Hae Cho, Suhwan Chang, Jung-Yun Lee, Jung Kyoon Choi
The paper identifies transcriptional HRD (tHRD) based on aberrant transcript usage as a more accurate predictor of PARP inhibitor and DNA damaging agent responses than genomic HRD tests.
Cancer Research · Oct 28, 2021Peer-reviewedGenetic & Genomic Medicine