Jung Kyoon Choi

This study identifies transcript usage remodeling in PARPi-resistant ovarian cancer through longitudinal RNA-sequencing, showing distinct patterns in acquired vs. innate resistance.

This study links tumor and immune cell profiles in NSCLC patients to their response to immune checkpoint inhibitors, finding higher CD4+ regulatory T cells and NF-kB/STAT3 activity in non-responders.

The paper identifies transcriptional HRD (tHRD) based on aberrant transcript usage as a more accurate predictor of PARP inhibitor and DNA damaging agent responses than genomic HRD tests.

The paper introduces the Cancer LncRNA Census (CLC), a curated resource of lncRNAs with causative roles in cancer, and shows their genomic and evolutionary features.

ActivePathways integrates multivariate omics data to identify enriched pathways, revealing cancer driver genes and prognostic pathways in breast cancer.

The paper identifies noncoding de novo mutations contributing to autism spectrum disorder by altering chromatin interactions and gene expression in neural stem cells.

The paper develops a convolutional neural network to predict causal noncoding variants with regulatory function in GWAS data, identifying variants in active regulatory regions and associated genes for psychiatric and autoimmune diseases.

The paper identifies immune-related factors that correlate with reduced L1 retrotransposition in gastrointestinal cancers.