Hyeon Gu Kang

This study identifies transcript usage remodeling in PARPi-resistant ovarian cancer through longitudinal RNA-sequencing, showing distinct patterns in acquired vs. innate resistance.

This study shows that ultraconserved poison exons regulate mitotic splicing fidelity and stem cell viability by controlling SR protein levels and splicing networks.

This study shows that bacterial species and individual donors differentially modulate airway gene expression and alternative splicing in human epithelial cells.

SpliceDecoder prioritizes biologically meaningful splicing events by predicting their impact on transcript productivity, protein sequence, and functional domains.

This study creates a single-cell aging atlas of mouse mammary tissues, identifying shared epigenomic and transcriptomic changes between aging and cancer.

The paper identifies transcriptional HRD (tHRD) based on aberrant transcript usage as a more accurate predictor of PARP inhibitor and DNA damaging agent responses than genomic HRD tests.