Chemogenetic attenuation of PFC pyramidal neurons restores deficits in recognition memory following adolescent NMDA receptor blockade
Hagar Bauminger, Sailendrakumar Kolatt Chandran, Hiba Zaidan, Irit Akirav, Inna Gaisler‐Salomon
This study shows that chronic MK-801 administration during early adolescence disrupts the E/I balance in the PFC, leading to recognition memory deficits, which can be reversed by chemogenetic attenuation of pyramidal neurons.
Progress in Neuro-Psychopharmacology and Biological Psychiatry · Apr 1, 2025Peer-reviewedNeuroscience