Sailendrakumar Kolatt Chandran

Chemogenetic attenuation of PFC pyramidal neurons restores deficits in recognition memory following adolescent NMDA receptor blockade

This study shows that chronic MK-801 administration during early adolescence disrupts the E/I balance in the PFC, leading to recognition memory deficits, which can be reversed by chemogenetic attenuation of pyramidal neurons.

Intrinsic excitability in layer IV-VI anterior insula to basolateral amygdala projection neurons encodes the confidence of taste valence

The paper shows that intrinsic excitability in layer IV-VI aIC-BLA neurons encodes taste valence confidence, modulated by novelty and valence, during CTA learning and memory retrieval.

Insula to mPFC reciprocal connectivity differentially underlies novel taste neophobic response and learning

This study investigates the role of aIC-mPFC reciprocal connectivity in novel taste neophobia and learning in mice, showing distinct functional roles for aIC-to-mPFC and mPFC-to-aIC projections.

Parvalbumin Interneurons Inhibition onto BLA Projecting Neurons of the Anterior Insula Orchestrates Aversive Taste Memory Retrieval

The paper identifies that parvalbumin interneurons inhibit anterior insula pyramidal neurons projecting to the basolateral amygdala during aversive taste memory retrieval, which is necessary for memory dominance.