Collagen type VI regulates TGFβ bioavailability in skeletal muscle
Payam Mohassel, Jachinta E. Rooney, Yaqun Zou, Kory R. Johnson, Gina Norato, Hailey Hearn, Matthew Nalls, Pomi Yun, Tracy Ogata, Sarah Silverstein, David A. Sleboda, Thomas J. Roberts, Daniel B. Rifkin, Carsten G. Bönnemann
This study identifies dysregulation of the TGFβ pathway in a mouse model of collagen VI-related disorders, linking ECM collagen VI deficiency to altered TGFβ bioavailability and muscle dysfunction.
bioRxiv · Jun 22, 2023 · PreprintNeuroscience