Liver-Derived, Circulating Xanthine Oxidoreductase Drives Vascular Impairment Associated with Inhalation of Ultrafine Particulates.
Xena M. Williams, Alec T. Bossert, Maddison Seman, Sara E. Lewis, Hailey McCallen, Josilyn Pilkerton, Elizabeth Compton Bowdridge, Mark A. Paternostro, William Travis Goldsmith, Timothy Robert Nurkiewicz, Salik Hussain, Eric E. Kelley, Evan DeVallance
This study shows that liver-derived, circulating xanthine oxidoreductase (XOR) contributes to vascular impairment caused by ultrafine particulate inhalation, with potential epigenetic mechanisms involved.
Free Radical Biology and Medicine · Jul 13, 2026Peer-reviewedPhysiology