Leveraging High-Throughput Proteomics and AI-Based Protein Folding to Accelerate VAV1 Molecular Glue Discovery
Hanfeng Lin, Xin Yu, Haiyang, Ran Cheng, Min Zhang, Xiaoli Qi, Yen‐Yu Yang, Shengmin Zhou, Rui Qi, Ly Le, Andrea Bortolato, Semen O. Yesylevskyy, Алан Нафієв, Xing Che, Jin Wang
This paper identifies a novel non-canonical RT-loop degron in VAV1 and demonstrates how conformational restriction and computational modeling enhance molecular glue potency for proteasomal degradation.
Nature Communications · Sep 12, 2026Peer-reviewedBiochemistry