Ly Le

Leveraging High-Throughput Proteomics and AI-Based Protein Folding to Accelerate VAV1 Molecular Glue Discovery

This paper identifies a novel non-canonical RT-loop degron in VAV1 and demonstrates how conformational restriction and computational modeling enhance molecular glue potency for proteasomal degradation.

VN1K: a genome graph-based and function-driven multi-omics and phenomics resource for the Vietnamese population

VN1K provides a comprehensive multi-omics and phenomics resource for the Vietnamese population, identifying novel variants and functional associations with disease traits and drug responses.

On improving experimental binding affinity predictions with synthetic data

The paper improves binding affinity predictions by using synthetic data, showing that combining synthetic and experimental data enhances model performance.