Dissection of central clock function in Drosophila through cell-specific CRISPR-mediated clock gene disruption
Rebecca Delventhal, Meghan Pantalia, Reed M. O'Connor, Matthew Ulgherait, Han X Kim, Maylis K Basturk, Julie C. Canman, Mimi Shirasu‐Hiza
The paper uses CRISPR to disrupt clock genes in specific Drosophila neurons, showing that neither the morning nor evening oscillator alone is sufficient for circadian locomotor activity, indicating a distributed network function.
eLife · Oct 15, 2019Peer-reviewedGenomics