Chromone scaffold-mediated reprogramming of the epithelial mesenchymal transition prevents fibrosis
Han-Soo Kim, Jun-Hwan Kim, Young-Min Yoon, Moon Kee Meang, Ji Yong Lee, Tae Hee Lee, Ik-Hwan Kim, Byung-Soo Youn
This study identifies eupatilin, a chromone scaffold compound, as a potent inhibitor of fibrosis by blocking epithelial-mesenchymal transition and TGFβ signaling in vitro and in a lung fibrosis model.
bioRxiv · May 15, 2018 · PreprintCell Biology