How and why ampliconic genes survive on the human Y chromosome
Karol Pal, Aleksandra Greshnova, Sukhwan Park, Byung June Ko, Hana Palova, Martin Steinegger, Sergei L. Kosakovsky Pond, Stefan Canzar, Kateryna D. Makova
The paper investigates how multicopy gene families on the human Y chromosome survive despite lack of recombination, showing that homogenization via palindromes and arrays, along with purifying selection, preserve protein structure essential for fertility.
bioRxiv · Apr 2, 2024 · PreprintGenomics