RPGR regulates motile cilia by interfering with actin dynamics
Yang Wu, Erika Sendra Tavares, Binrun Liang, Wallace B. Wee, Vito Mennella, Hanchao Feng, Jiaying Cao, Jiayi Zheng, Mu He, Kirk A. J. Stephenson, Liran Hanan, Janice Min Li, Sharon Dell, Elise Héon, Zhen Liu
This study shows RPGR variants impair motile cilia in airway multiciliated cells by causing apical F-actin accumulation, leading to reduced ciliation, shorter cilia, and impaired cilia beat.
bioRxiv · Mar 13, 2025 · PreprintCell Biology