Efficacy and mechanism of action of cipargamin as an antibabesial drug candidate
Hang Li, Shengwei Ji, Nanang Rudianto Ariefta, Eloiza May Galon, Shimaa AES El-Sayed, Thom Do, Lijun Jia, Miako Sakaguchi, Masahito Asada, Yoshifumi Nishikawa, Xin Qin, Mingming Liu, Xuenan Xuan
This study evaluates cipargamin's efficacy against Babesia species and identifies resistance mechanisms, showing its effectiveness as an anti-babesial drug but limitations due to resistance, with combination therapy with tafenoquine offering potential.
eLife · Jun 2, 2025Peer-reviewedMicrobiology