The spontaneous neoantigen-specific CD4+ T cell response to a growing tumor is functionally and phenotypically diverse.
Ryan Q. Griswold, Spencer E. Brightman, Karla Soria Zavala, Manuel Azaid Ordaz-Arias, Navid Djassemi, Rukman R. Thota, Martin S. Naradikian, Hannah Dose, Suzie Alarcón, Pandurangan Vijayanand, Bjoern Peters, Aaron M. Miller, Ezra E.W. Cohen, Stephen Philip Schoenberger
This study characterizes the phenotypic and functional diversity of neoantigen-specific CD4+ T cell responses to a growing tumor and shows how immunotherapy alters their composition and efficacy.
Journal for ImmunoTherapy of Cancer · Sep 1, 2025Peer-reviewedImmunology