Stephen Philip Schoenberger

SUMO2 Deletion Changes Chromatin Accessibility and Enhances Cytotoxic T Cell Activation and Tumor Infiltration

This study shows that deleting SUMO2 in CD8+ T cells enhances their activation, tumor infiltration, and anti-tumor effects by altering chromatin accessibility and gene expression.

Identification of pre-existing ubiquitous neoantigen-reactive tumor-infiltrating T-cells in a patient with metastatic pancreatic neuroendocrine tumor

This study identifies a ubiquitous neoantigen-reactive T-cell response across multiple metastatic sites in a patient with pancreatic neuroendocrine tumor, supporting the use of mutation-sharing status for neoantigen selection in immunotherapy.

The spontaneous neoantigen-specific CD4+ T cell response to a growing tumor is functionally and phenotypically diverse.

This study characterizes the phenotypic and functional diversity of neoantigen-specific CD4+ T cell responses to a growing tumor and shows how immunotherapy alters their composition and efficacy.

Machine learning of three-dimensional protein structures to predict the functional impacts of genome variation

This paper develops a machine learning method using protein structures to predict the functional impacts of genetic variants on transcriptional pathways of Nrf2 and c-MYC.

Combined assessment of MHC binding and antigen expression improves T cell epitope predictions

This paper improves T cell epitope predictions by combining MHC binding affinities with antigen expression levels, showing better performance than methods using only binding or expression data.