A synthetic stroma-free germinal center niche using material-surface driven polyvalent signaling efficiently induces antigen-specific humoral immunity ex vivo
Kyung-Ho Roh, Hannah K. Wilson, Pallab Pradhan, Kevin Bai, Caitlin D. Bohannon, Gordon Dale, Jardin Leleux, Joshy Jacob, Krishnendu Roy
This paper develops a synthetic germinal center niche that induces antigen-specific humoral immunity ex vivo by mimicking follicular T helper and dendritic cells.
bioRxiv · Sep 27, 2017 · PreprintBioengineering