Recruitment of CTCF to an Fto enhancer is responsible for transgenerational inheritance of obesity
Yoon Hee Jung, Hsiao‐Lin V. Wang, Daniel Ruíz, Fiorella Carla Grandi, Brianna J. Bixler, Hannah Linsenbaum, Jian‐Feng Xiang, Samantha Forestier, Andrew M. Shafik, Peng Jin, M. Ryan Corces, Victor G. Corces
This study shows that BPA exposure in pregnant mice leads to transgenerational obesity via CTCF binding at Fto enhancers, which affects neural stem cells and AgRP/NPY neurons.
bioRxiv · Nov 20, 2020 · PreprintGenomics