Hsiao‐Lin V. Wang

Temporal regulation of human reactive astrocytes reveals their capacity for antigen presentation

This study shows human astrocytes can present antigens via MHCII after chronic cytokine exposure, revealing their potential as antigen-presenting cells.

Uncovering the dark transcriptome in polarized neuronal compartments with mcDETECT

The paper introduces mcDETECT, a machine learning framework for detecting RNA granules in spatial transcriptomics data, revealing functionally distinct neuronal substates and early Alzheimer's disease pathology.

pTDP-43 levels correlate with cell type specific molecular alterations in the prefrontal cortex of C9orf72 ALS/FTD patients

The paper identifies cell type-specific molecular changes in the prefrontal cortex of C9orf72 ALS/FTD patients correlated with pTDP-43 levels.

Ectopic transcription due to inappropriately inherited histone methylation may interfere with the ongoing function of terminally differentiated cells

The paper shows that mutations in histone modifying enzymes cause ectopic gene expression in adult worms, leading to behavioral defects that may be reversible.

Characterization of a strain-specific CD-1 reference genome reveals potential inter- and intra-strain functional variability

The paper identifies millions of previously unknown genetic variants in CD-1 mice and constructs a strain-specific reference genome to improve sequencing accuracy and reduce bias.

Exposure to sevoflurane results in changes of transcription factor occupancy in sperm and inheritance of autism

Exposure to sevoflurane in pregnant mice leads to behavioral impairments in F1 offspring, which are transmitted to F2 and F3 generations through altered transcription factor occupancy in sperm.

Recruitment of CTCF to an Fto enhancer is responsible for transgenerational inheritance of obesity

This study shows that BPA exposure in pregnant mice leads to transgenerational obesity via CTCF binding at Fto enhancers, which affects neural stem cells and AgRP/NPY neurons.