Victor G. Corces

The paper shows that properly purified cauda sperm lack somatic contamination and that pretreatment disrupts chromatin structure, validating untreated sperm profiles.

This study identifies NKX2-1-driven epigenetic and 3D chromatin remodeling as key to neuroendocrine prostate cancer progression and reveals CBP/p300 inhibitors as potential therapeutic targets.

The paper introduces mcDETECT, a machine learning framework for detecting RNA granules in spatial transcriptomics data, revealing functionally distinct neuronal substates and early Alzheimer's disease pathology.

The paper identifies cell type-specific molecular changes in the prefrontal cortex of C9orf72 ALS/FTD patients correlated with pTDP-43 levels.

The paper shows that mutations in histone modifying enzymes cause ectopic gene expression in adult worms, leading to behavioral defects that may be reversible.

The paper identifies millions of previously unknown genetic variants in CD-1 mice and constructs a strain-specific reference genome to improve sequencing accuracy and reduce bias.

The paper uses ultra-deep Hi-C and a new computational method to fine-map nuclear compartments, revealing that active promoters and enhancers localize in the A compartment even when adjacent sequences are inactive.

The paper identifies different types of compartmental domains in human chromosomes and presents a computational model to predict their organization based on chromatin features.

Exposure to sevoflurane in pregnant mice leads to behavioral impairments in F1 offspring, which are transmitted to F2 and F3 generations through altered transcription factor occupancy in sperm.

This study shows that replication timing (RT) is essential for maintaining the global epigenetic state and genome compartmentalization in human cells, with RIF1 playing a central role in this process.

This study shows that BPA exposure in pregnant mice leads to transgenerational obesity via CTCF binding at Fto enhancers, which affects neural stem cells and AgRP/NPY neurons.

The paper shows that transcription factors maintain CpG methylation during reprogramming of primordial germ cells and embryos, preserving epigenetic information across generations.

The paper investigates transcriptional and chromatin changes in hippocampal neurons during and after activation, identifying immediate and long-term epigenomic signatures linked to neuroplasticity.

The paper identifies chromatin changes in Anopheles gambiae mosquitoes infected with Plasmodium falciparum using ChIP-seq and RNA-seq, revealing differentially enriched histone modifications and associated genes involved in immune responses.